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KMID : 0377519770020010011
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Chung-Ang Journal of Medicine
1977 Volume.2 No. 1 p.11 ~ p.18
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Effect of Mouse Lung Passages of Influenza Virus on the Hypothermia of Mice
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Lim Kiu-Hong
Yang Yong-Tae
Choi Chul-Soon
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Abstract
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Through mouse lung passages (up to the 7th) of egg-adapted line of influenza virus type A PR 8 strain (A/PR/8/34 (H_0N_1)) in Balb/C mice at 3 days intervals, the developments of hypothermia, lung virus titers and lung lesions were followed. The results are summarized as follows: 1. There observed concomitant increases in the extents of both hypothermia and lung lesions as the levels of mouse lung passages of egg-line virus were increased. 2. It was confirmed that time of occurrence and degree of hypothermia in the mice inoculated with mouse-passaged virus was closely related to the extent of pulmonary lesions. 3. Though there occurred a little change in the virus titers of mouse lungs through serial passages, a significant increase was observed in LD_50 of mouse-passaged virus in comparison with egg-line virus.
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